Arimidex versus tamoxifen

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    Arimidex versus tamoxifen


    DCIS (ductal carcinoma in situ) is the most common form of non-invasive breast cancer and is considered stage 0 cancer. While DCIS isn’t life threatening, it increases the risk of developing invasive breast cancer later in life. DCIS usually is treated with surgery to remove the cancer -- lumpectomy in many cases. After surgery, many women have radiation therapy to reduce the risk of DCIS coming back (recurrence). If the DCIS is hormone-receptor-positive (most are), hormonal therapy also usually is recommended after surgery. Of the adjuvant hormonal therapy choices, tamoxifen has been approved the longest and is approved to treat both premenopausal and postmenopausal women. Tamoxifen comes in both pill and liquid form and is usually taken once per day. Bonnie Annis is a breast cancer survivor, diagnosed in 2014 with stage 2b invasive ductal carcinoma with metastasis to the lymph nodes. She is an avid photographer, freelance writer/blogger, wife, mother and grandmother. The decision to walk away from taking aromatase inhibitors is a choice many women are now making. No longer do they blindly follow the advice of doctors to take medication for the next five to 10 years that may or may not prevent the recurrence of breast cancer. They’re doing their homework and learning more about the potential side effects of drugs like Tamoxifen, arimidex, aromasin and femara. Their health care responsibility has shifted from the shoulders of their medical team into their own capable hands as women are discovering they have a right to choose. Standard adjuvant therapies after a breast cancer diagnosis often include one or more of the following: chemotherapy, radiation treatments, surgery or long-term medications such as SERMS (selective estrogen receptor modulators). According to an article posted by Breastcancer.org, “Tamoxifen, the generic name of nolvadex, is the oldest and most-prescribed SERM.” It has been used in both women and men diagnosed with hormone receptor-positive breast cancers to reduce the possibility of recurrence.

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    Arimidex versus tamoxifen. By. 2002 was a long time ago and tests underway then still confirm today the benefits of Arimidex over tamoxifen in postmenopausal women. Arimidex is not prescribed. Arimidex, for example, is only licensed for postmenopausal women, while tamoxifen can be used in pre- and postmenopausal women as well as men. When considering Arimidex vs. tamoxifen, cost, whether generic versions are available, and study results may also be taken into account. With an average of four years of treatment on the ATAC study, hormone receptor-positive participants taking Arimidex were 22 percent more likely to be cancer-free than those taking tamoxifen 304 patients on Arimidex vs. 363 patients on tamoxifen experienced recurrence.

    This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. 14, 2007 (San Antonio) -- Even after treatment ends, Arimidex beats out tamoxifen in preventing breast cancer recurrence in women with hormone-fueled tumors. Updated results from this landmark trial also show that the increased risk of fractures associated with Arimidex therapy disappears after treatment stops. In the study, more than 5,000 women with hormone-receptor-positive tumors were followed for more than three years after treatment was stopped. The researchers show that an additional 25% of recurrences were prevented by Arimidex, compared with tamoxifen, says John F. Forbes, MD, professor of surgery at the University of Newcastle in Australia. During treatment, nearly 3% of women taking Arimidex had bone fractures vs. More than three years after treatment ended, the percentage was about 1.5% in both groups. With this kind of information on patient-reported outcomes in women with ductal carcinoma in situ, patients and their physicians can now make personalized decisions on which of these two effective agents [anastrozole vs tamoxifen] to select. Ductal carcinoma in situ is a relatively benign form of breast cancer (stage 0), yet up to 10% of women with ductal carcinoma in situ will have a recurrence within 10 years. At present, there is no way to identify which women will recur, so standard treatment is lumpectomy plus radiation therapy. Hormonal therapy is offered to women with estrogen receptor–positive ductal carcinoma in situ to prevent recurrence. Two studies presented at the 2015 San Antonio Breast Cancer Symposium shed some light on how women with ductal carcinoma in situ who choose to take a hormonal agent can make the decision, in consultation with their oncologists, between an aromatase inhibitor, anastrozole, and tamoxifen. The bottom line is that the choice depends on patient preferences, side-effect profiles, and other risk factors. The first study presented final results of the large, placebo-controlled IBIS-II DCIS trial that compared tamoxifen vs anastrozole in 2,980 postmenopausal women with ductal carcinoma in situ.

    Arimidex versus tamoxifen

    Breast Cancer Arimedex vs. Tamoxifen - WebMD, Arimidex vs. Tamoxifen - Breast Cancer Home Page

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  4. During treatment, nearly 3% of women taking Arimidex had bone fractures vs. only 2% on tamoxifen. More than three years after treatment ended, the percentage was about 1.5% in both groups.

    • Breast Cancer Arimidex vs. Tamoxifen - WebMD.
    • Ask an Expert Tamoxifen vs. Arimidex? Providence Oregon.
    • The Choice to Walk Away From Aromatase Inhibitors - Cure Today.

    Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally excised ductal carcinoma in situ IBIS-II DCIS a double-blind, randomised controlled trial" Dec 12, 2015. "Anastrozole versus tamoxifen for the prevention of locoregional and contralateral breast cancer in postmenopausal women with locally. Comparison of anastrozole versus tamoxifen as preoperative therapy in postmenopausal women with hormone receptor-positive breast cancer the.

     
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