Tamoxifen citrate is also being studied in the treatment of other types of cancer. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. Medline Plus Information on Tamoxifen Citrate - A lay language summary of important information about this drug that may include the following: Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied. Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival Hormone Therapy for Breast Cancer Exemestane Following Tamoxifen Reduces Breast Cancer Recurrences and Prolongs Survival Study Confirms Letrozole Prevents More Breast Cancer Recurrences Than Tamoxifen Long-Term Data from 20 Trials Confirm Tamoxifen’s Long-Lasting Benefit Tool Weighs Benefits, Risks of Raloxifene or Tamoxifen to Prevent Breast Cancer Five Years of Tamoxifen Continues to Benefit Women 15 Years after Treatment Targeted Cancer Therapies Find Clinical Trials for Tamoxifen Citrate - Check for trials from NCI's list of cancer clinical trials now accepting patients. Important: The drug information on this page is meant to be educational. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Chemical name: Tamoxifen Pill brand names: Nolvadex, Apo-Tamox, Tamofen, Tamone Liquid brand name: Soltamox Class: SERM (selective estrogen receptor modulator) hormonal therapy. How it works: SERMs block the effects of estrogen in the breast tissue by attaching to the estrogen receptors in breast cells. Uses: Tamoxifen, used to treat men and both premenopausal and postmenopausal women, typically is used to:gene that makes a version of the CYP2D6 enzyme that doesn’t function as well as it should. Having a low-functioning CYP2D6 enzyme might keep a person from getting the full benefit of tamoxifen. In 2018, the Clinical Pharmacogenetics Implementation Consortium, an international group of scientists that issues guidelines on the effects of genetic factors on reactions to drugs, issued a guideline on using genotype that makes them less able to metabolize tamoxifen be treated with a different type of hormonal therapy, such as an aromatase inhibitor. You may want to ask your doctor about being tested for this genetic abnormality if you are considering taking tamoxifen. Also, certain medications can block the activity of the CYP2D6 enzyme, including antidepressants known as SSRIs and SNRIs, as well as Benadryl (chemical name: diphenhydramine) and Tagamet (chemical name: cimetidine). Make sure you tell your doctor about ALL other medicines you're taking if you're considering taking tamoxifen to make sure you get the full benefit of treatment. Metformin drug Levitra effectiveness For some women with breast cancer, taking adjuvant tamoxifen. The improved outcomes with longer tamoxifen use emerged only after the. Tamoxifen is approved by the FDA for adjuvant hormone treatment of premenopausal and postmenopausal women and men with ER-positive early-stage breast cancer, and the aromatase inhibitors anastrozole and letrozole are approved for this use in postmenopausal women. WebMD looks at the use of the drug tamoxifen for treating breast cancer and preventing it in high-risk cases. But they do know that some breast cancer cells are sensitive to estrogen. In order to fuel that growth, estrogen must attach itself to those breast cancer cells. Doctors think that tamoxifen stops estrogen from attaching to the cell. No estrogen means no growth for these types of breast cancer cells. Tamoxifen also keeps healthy breast cells from growing and multiplying. That way, it also reduces the number of cells that could become cancer. In a study of more than 13,000 women at high risk for breast cancer, scientists found that women who took tamoxifen for 5 years had fewer breast cancers than women who took a placebo. Newer research suggests that taking the drug for 10 years lowers the risk even more. Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Learn about tamoxifen and other hormone therapies for metastatic breast cancer. Hormone receptor-positive breast cancers need estrogen and/or progesterone (female hormones produced in the body) to grow. Tamoxifen attaches to the hormone receptor in the cancer cell, blocking estrogen from attaching to the receptor. This slows or stops the growth of the tumor by preventing the cancer cells from getting the hormones they need to grow. Tamoxifen is a pill taken every day for 5-10 years. For premenopausal women, tamoxifen may be combined with ovarian suppression. The benefits from tamoxifen last long after you stop taking it. Tamoxifen use in breast cancer Hormone Therapy for Breast Cancer - National Cancer Institute, Hormone Therapy for Breast Cancer Fact Sheet - National. Lasix loop diuretic Tamoxifen is a hormone therapy drug used to treat ER+ breast cancer in pre- and post-menopausal women. Learn about how tamoxifen works and its side effects at Breast. Tamoxifen Breast Cancer Care. Tamoxifen for Breast Cancer Treatment and Prevention. Tamoxifen for Breast Cancer Treatment - Side Effects Susan G.. Tamoxifen Nolvadex is a medication used to treat hormone-receptor positive early and metastatic breast cancers and to reduce breast cancer risk in undiagnosed women. Tamoxifen Nolvadex, a hormone therapy drug, is used to treat breast cancers and to lower risk in women at high risk of breast cancer. Read about Tamoxifen side-effects here. Tamoxifen blocks the actions of estrogen and is used to treat and prevent some types of breast cancer. Learn about side effects, interactions and indications.