Tamoxifen memory loss

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  1. SAlfred Guest

    Tamoxifen memory loss


    Memory is your mind's ability to keep and remember information. You go to another room to get something, only you forget what you needed when you get there. Maybe you can't find your car keys one day and your glasses the next. These occasional memory lapses are normal signs that your brain is a little overworked. But memory loss also can be part of a bigger problem that's more serious than just misplaced car keys. If you answer “yes” to them, ask your doctor to evaluate your memory loss. There are other treatment side effects that can affect your memory, including trouble sleeping and fatigue. Memory loss also can be a side effect of other medicines, such as steroids, anti-depressants, sleeping pills, and pain medications. Talk to your doctor if you think a medication may be contributing to your memory loss. A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to “chemo brain.”However, in the Journal of Neuroscience, researchers also report they’ve discovered an existing drug compound that appears to counteract or rescue brain cells from the adverse effects of the breast cancer drug. D., professor of Biomedical Genetics and director of the UR Stem Cell and Regenerative Medicine Institute, said it’s exciting to potentially be able to prevent a toxic reaction to one of the oldest and most widely used breast cancer medications on the market. Although tamoxifen is more easily tolerated compared to most cancer treatments, it nonetheless produces troubling side effects in a subset of the large number of people who take it. By studying tamoxifen’s impact on central nervous system cell populations and then screening a library of 1,040 compounds already in clinical use or clinical trials, his team identified a substance known as AZD6244, and showed that it essentially eliminated tamoxifen-induced killing of brain cells in mice.“As far as I know, no one else has discovered an agent that singles out and protects brain and central nervous system cells while also not protecting cancer cells,” said Noble, who also collaborates with researchers at the UR's James P. “This creates a whole new paradigm; it’s where we need to go.”The research is the result of two separate but related projects from Noble’s lab. One investigates the science underlying a condition known as “chemo brain,” and another is looking at how to exploit tamoxifen’s attributes for use in other types of cancer besides early-stage, less-aggressive breast cancer. (The drug is a type of hormonal therapy, which works by stopping the growth of estrogen-sensitive tumors.)In the Journal of Neuroscience paper, Noble’s team first identified central nervous system (CNS) cells that are most vulnerable to tamoxifen toxicity. Chief among these were oligodendrocyte-type 2 astrocyte progenitor cells (O-2A/OPCs), cells that are essential for making the insulating sheaths (called myelin) required for nerve cells to work properly. Exposure to clinically relevant levels of tamoxifen for 48 hours killed more than 75 percent of these cells.

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    Tamoxifen and toremifene cause impairment of learning and memory function in mice. Pharmacol Biochem Behav. 2002;9–76. PubMed. I have been on Tamoxifen for 4 years and did not undergo chemo. I am having memory issues as well. I used to be able to keep everything in my brain, now I have o write things down. I struggle with word recall and names. There are so many side effects of tamoxifen, but memory If your memory loss is a side effect of breast cancer treatment, try the following tips to help stimulate your memory Exercise your brain by keeping mentally active with word puzzles, reading. Keep a note pad nearby to jot down things you have to do and ideas you have. Use a calendar to keep.

    I'm not sure if there is a thread on this, but I wanted to know if anyone out there is having difficulty w/tamoxifen when it comes to memory loss. I was never great to begin with, but my short-term memory is literally abysmal these days. I feel like it has to do with the drug which I've now been taking for exactly two years. (I'm still on my first line treatment of Tamoxifen and Lupron.) If you have this problem, please let me know and let me know what you're doing to address it. Log in to post a reply Mar 3, 2017 AM blainejennifer wrote: I'm just spitballing here, but it seems that estrogen depletion will lead to some memory loss, so it could be the Lupron. Ladies who don't have cancer report memory loss as a part of the menopause. Personally, I've had to keep a small notebook with me all the time to jot things into, and I have to check it each night. And, yes, a lot of us ER/PR ladies here have been vaulted into senior moments by the various estrogen depleting maneuvers we have done/have had done to us. Also, get a big calendar that you can write on, and keep it in a prominent place and train yourself to update and check it daily (it also makes a nice record for medical appointments and treatment courses). I also found a pliable refrigerator magnetic whiteboard that has come in handy for household chores and shopping lists. But, not quite as badly as if I had no coping mechanisms. Jennifer Mar 3, 2017 PM Goodie16 wrote: I'm not on tamoxifen anymore, but am on Arimidex. I guess you don't realize how much estrogen does for your body until it's gone! Mar 3, 2017 PM Moderators wrote: Hi bloomingdale, Yes, this seems to be a very common side effect of breast cancer and also its treatment, including hormonal and chemotherapies. Women who took tamoxifen for a year or more were found to score lower on verbal memory and executive functioning tests, according to researchers at the Netherlands Cancer Institute in Amsterdam. Their results were published this month in the online version of the Journal of Clinical Oncology. Tamoxifen was first approved by the FDA in 1971 for the treatment of breast cancer. Originally developed by Astra Zeneca under the brand name Nolvadex, it is now sold under a variety of brand names, including Istubal and Valodex, and is also sold as a generic. Tamoxifen works by inhibiting the development of estrogen, which is believed to stimulate the spread of breast cancer. As of 2004, it was the largest selling hormone-based breast cancer treatment drug in the world. Dutch researchers, funded by Pfizer, tested 299 women, including 80 women prescribed tamoxifen and 99 women taking Pfizer’s competing Aromasin (exemestane).

    Tamoxifen memory loss

    Breast Cancer Topic Tamoxifen and Memory Loss, Tamoxifen Brain - true or made up Cancer Survivors Network

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  7. Mental Fog with Tamoxifen is Real; Scientists Find. some people continue to endure short-term memory loss. In mice co-treated with tamoxifen.

    • Mental Fog with Tamoxifen is Real; Scientists Find Possible..
    • Memory Loss A Side Effect of Treatment -.
    • Tamoxifen's Mental Side Effects Are Real, Study Shows – WebMD.

    Hormonal therapies, such as tamoxifen and aromatase inhibitors anastrozole, letrozole and exemestane, may also affect your memory and concentration. Feeling extremely tired fatigue is a common side effect of cancer treatment. Having these symptoms treated may improve problems with your concentration. Tamoxifen Side Effects Can Hamper Memory, Cognitive Ability Study The results of a new study suggest that side effects of tamoxifen, a breast cancer drug. Women who took tamoxifen for a year or more were found to score lower on verbal memory. Tamoxifen was first approved by the FDA in 1971. Although tamoxifen is more easily tolerated compared to most cancer. in this area, some people continue to endure short-term memory loss.

     
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    "Steroids" are a family of chemicals normally made within the body. They serve as hormones —chemical signals that help to regulate the body's growth and function. Some steroid hormones, like testosterone, stimulate formation of protein and growth of muscle. Competitive athletes have been known to take illicitly derivatives of these "body-building" steroids in large amounts to improve their athletic performance. A very different group of steroid hormones are the corticosteroids, steroid hormones made in the cortex (hence, "cortico-") of the adrenal glands, which sit adjacent to the kidneys. Corticosteroid hormones have many different affects on body function, including influences on how we use our energy stores (fat, protein, and sugar) and how we adjust the salt and water content of our body. Early in this century it was discovered that corticosteroid hormones, if purified and taken in large amounts as a medicine, have powerful anti-inflammatory effects. Prednisone Reviews Everyday Health Prednisone Uses, Dosage, Side Effects, Warnings - Can I stop taking prednisone after taking it for 3 days? -
     
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    People treated with appropriate antibiotics in the early stages of Lyme disease usually recover rapidly and completely. Antibiotics commonly used for oral treatment include doxycycline, amoxicillin, or cefuroxime axetil. People with certain neurological or cardiac forms of illness may require intravenous treatment with antibiotics such as ceftriaxone or penicillin. Treatment regimens listed in the following table are for localized (early) Lyme disease. See references below (Hu 2016; Sanchez 2016) for treatment of patients with disseminated (late) Lyme disease. These regimens are guidelines only and may need to be adjusted depending on a person’s age, medical history, underlying health conditions, pregnancy status, or allergies. For people intolerant of amoxicillin, doxycycline, and cefuroxime axetil, the macrolides azithromycin, clarithromycin, or erythromycin may be used, although they have a lower efficacy. Treatment Lyme Disease CDC Doxycycline antibiotic to treat bacterial infections - NHS Doxycycline Oral Route Precautions - Mayo Clinic
     
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